Varicocele and sperm damage

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Alteration of testicular microvascular pressures during venous pressure elevation. We followed up the patients for 3 and 6 months, and seminal analysis were performed to evaluate changes in the seminal indices. Material and methods Ankara University School of Medicine ethics committee approved the study, and written consent was obtained from the participants. Clinical, hormonal and biochemical investigation. There were no documented diseases that would affect the results. A number of studies have proposed that the presence of spermatozoa with damaged DNA may be the result of an impaired chromatin packing or may be indicative of apoptosis Sakkas et al.

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The postoperative outcomes of varicocelectomy operation in patients with normal sperm count but with sperms having abnormal morphology and impaired motility have not been studied much.

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Male infertility and varicocele: myths and reality

Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Different hypotheses have been proposed to explain the origin of DNA damage in mature spermatozoa from infertile men, including abnormalities in chromatin packing, microdeletions, aneuploidy, chromosomal rearrangements, DNA strand breaks and apoptosis Gorczyca et al. Several other recent studies have evaluated DNA structure and integrity in human ejaculated sperm samples and have reported a negative effect of high percentages of DNA-damaged spermatozoa on pregnancy rates Larson et al. Oxidative stress, DNA damage and the Y chromosome. Additionally, the total and motile sperm counts were significantly lower in that group, which is consistent with previously reported results.

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